219907-83-2Relevant academic research and scientific papers
Generation of near-enantiopure α-alkyl α-formyl α-hydroxy ketones/esters and their interception with ethoxycarbonylmethylenetriphenylphosphorane
Bhatia, Gurpreet S.,Lowe, Richard F.,Stoodley, Richard J.
, p. 9245 - 9248 (1998)
Two protocols for the generation of the (R)-enantiomers of α-alkyl α- formyl α-hydoxy ketones/esters in states of high enantiomeric purity are developed; the formyl functions of such compounds undergo Wittig condensations with ethoxycarbonylmethylenetriphenylphosphorane in dimethyl sulfoxide to afford the corresponding alkenes with high (E)- stereoselectivities and with e.e.s of 91-99%.
