219920-38-4Relevant articles and documents
Isolation and synthesis of an α-malamic acid derivative from Justicia ghiesbreghtiana
Ismail, Lotfy D.,Lorenz, Peter,Stermitz, Frank R.
, p. 1174 - 1176 (2007/10/03)
A polar extract of leaves of Justicia ghiesbreghtiana yielded N-(2- hydroxy-4,5-dimethoxyphenyl)(S)-α-malamic acid, 1. Incomplete spectral analysis yielded a hypothetical structure, which was then proven by total synthesis. Coupling of the trifluoroacetate of malic anhydride (trifluoroacetoxysuccinic anhydride) with an arylamine provided the key to regiospecific preparation of the α- rather than β-malamic acids.