219920-69-1Relevant academic research and scientific papers
Design, synthesis and evaluation of carbamate-modified (-)-N1-phenethylnorphysostigmine derivatives as selective butyrylcholinesterase inhibitors
Takahashi, Jun,Hijikuro, Ichiro,Kihara, Takeshi,Murugesh, Modachur G.,Fuse, Shinichiro,Tsumura, Yoshinori,Akaike, Akinori,Niidome, Tetsuhiro,Takahashi, Takashi,Sugimoto, Hachiro
scheme or table, p. 1721 - 1723 (2010/06/19)
We synthesized carbamate-modified (-)-N1-phenethylnorphysostigmine derivatives 3a-u and evaluated their anti-cholinesterase activities. In vitro evaluation showed that cyclohexylmethylcarbamate derivative 3u potently and selectively inhibits bu
Preparation and Selective Inhibition of Human Butyrylcholinesterase by N1-Phenethylnorphysostigmine Analogues
Pei, Xue-Feng,Greig, Nigel H.,Bi, Sheng,Brossi, Arnold
, p. 455 - 461 (2007/10/03)
N1-Phenethylnorphysostigmine (13) and 3 arylcarbamate analogues (14-16) were prepared by a novel route. These compounds are less active inhibitors of human acetylcholinesterase (AChE) but more potent and selective inhibitors of human butyrylcho
