219923-05-4Relevant academic research and scientific papers
Asymmetric synthesis of (S)-(-)-N-acetylcolchinol via Ullmann biaryl coupling
Broady, Simon D.,Golden, Michael D.,Leonard, John,Muir, James C.,Maudet, Mickael
, p. 4627 - 4630 (2008/02/06)
A modified Ziegler Ullmann coupling process has been developed as the key step in an effective synthesis of (S)-(-)-N-acetylcolchinol, analogues of which are selective vascular targeting agents with potential importance in cancer chemotherapy. Asymmetric induction is achieved by enamide hydrogenation using FerroTANE catalysts.
CHEMICAL PROCESS
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Page/Page column 14-15, (2008/06/13)
Process for preparing a phosphorylated colchinol derivative of formula (I): wherein each R, which may be the same or different, is selected from (1-6C)alkyl, benzyl and C(O)(1-6C)alkyl, or two RO groups together form a (1-4C)alkylenedioxy group; by hydrolysing a compound of formula (II) wherein X is halogeno and each R is as hereinbefore defined. Processes for crystallising compounds of formula (I) and for preparing compounds of formula (II) are also described.
Colchicine derivatives, process for preparing them, products obtained therefrom and use thereof
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Page 5, (2008/06/13)
This invention discloses and claims processes for preparing colchicine derivatives, products obtained by these processes, and use thereof. More specifically, the invention relates essentially to a process for preparing organophosphorus compounds and their salts, having therapeutic activity, in particular in oncology.
