219923-05-4 Usage
Description
ZM 445526, also known as R77670, is a potent and selective inhibitor of the enzymes farnesyl protein transferase (FPT) and geranylgeranyl protein transferase (GGPT). These enzymes play a crucial role in post-translational lipid modification of proteins, and their inhibition can disrupt key signaling pathways involved in cell growth and survival. ZM 445526 has been studied for its potential as an anti-cancer agent, as it may block the action of oncoproteins that require farnesylation or geranylgeranylation for their function. Furthermore, it has been investigated for its potential in treating other diseases such as progeria, which is caused by a mutation in a protein involved in prenylation. Overall, ZM 445526 shows promise as a therapeutic agent for targeting diseases associated with abnormal protein prenylation.
Used in Pharmaceutical Industry:
ZM 445526 is used as an anti-cancer agent for its ability to block the action of oncoproteins that require farnesylation or geranylgeranylation for their function, potentially disrupting key signaling pathways involved in cell growth and survival.
Used in Treatment of Progeria:
ZM 445526 is used as a potential therapeutic agent for treating progeria, a disease caused by a mutation in a protein involved in prenylation, due to its ability to inhibit enzymes involved in post-translational lipid modification of proteins.
Check Digit Verification of cas no
The CAS Registry Mumber 219923-05-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,9,9,2 and 3 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 219923-05:
(8*2)+(7*1)+(6*9)+(5*9)+(4*2)+(3*3)+(2*0)+(1*5)=144
144 % 10 = 4
So 219923-05-4 is a valid CAS Registry Number.
219923-05-4Relevant articles and documents
Asymmetric synthesis of (S)-(-)-N-acetylcolchinol via Ullmann biaryl coupling
Broady, Simon D.,Golden, Michael D.,Leonard, John,Muir, James C.,Maudet, Mickael
, p. 4627 - 4630 (2008/02/06)
A modified Ziegler Ullmann coupling process has been developed as the key step in an effective synthesis of (S)-(-)-N-acetylcolchinol, analogues of which are selective vascular targeting agents with potential importance in cancer chemotherapy. Asymmetric induction is achieved by enamide hydrogenation using FerroTANE catalysts.
Colchicine derivatives, process for preparing them, products obtained therefrom and use thereof
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Page 5, (2008/06/13)
This invention discloses and claims processes for preparing colchicine derivatives, products obtained by these processes, and use thereof. More specifically, the invention relates essentially to a process for preparing organophosphorus compounds and their salts, having therapeutic activity, in particular in oncology.
