219938-60-0

Upstream product

• 84945-00-6 6-hydroxy-4,4,5,8-tetramethylhydrocoumarin 
• 106-95-6 allyl bromide 
• 615-90-7 2,5-dimethylhydroquinone 
• 137-18-8 2,5-Dimethyl-1,4-benzoquinone 
• 95-87-4 2,5-Dimethylphenol 
• 541-47-9 3-Methylbutenoic acid 

Downstream Products

• 1353713-42-4 3-(6-(methoxymethoxy)-4,4,5,8-tetramethylcoumarin-7-yl)propyl 4-methylbenzenesulfonate 

Relevant academic research and scientific papers

A Quencher-Fluorophore-Type Probe for Detection and Imaging of NADPH in Human Breast Cancer Cells

A new fluorogenic trimethyl lock quinone (TLQ) derivative, designated as the quencher-TLQ-fluorophore-type probe (Q-TLQ-F), was developed for selective detection of nicotinamide adenine dinucleotide phosphate (NADPH). By taking advantage of the well-known facile intramolecular ring cyclization reaction (δ-lactonization) of TLQ that can release a reporter molecule upon reduction, Q-TLQ-F was successfully applied for the detection of physiological NADPH generated by glucose-6-phosphate dehydrogenase in human breast cancer MDA-MB-231 cells.

Electrochemical "switching" of Si(100) modular assemblies

We report on a modular approach for producing well-defined and electrochemically switchable surfaces on Si(100). The switching of these surfaces is shown to change a Si(100) surface from resistant to cell adsorption to promoting cell adhesion. The electrochemical conversion of the modified electrode surface is demonstrated by X-ray photoelectron spectroscopy, X-ray reflectometry, contact angle and cell adhesion studies.

Anti-tumor agents

The invention concerns anti-tumor agents of formula (I), wherein each of R1, R2and R3has the meanings defined in the specification including hydrogen, (1-4C)alkyl, (3-4C)alkynyl and (1-4C)alkoxyl; each of R4and

Anti-tumuor agents

The invention concerns anti-tumour agents of formula (I) wherein each of R1, R2and R3has the meanings defined in the specification including hydrogen, (1-4C)alkyl, (3-4)alkenyl, (3-4C)alkynyl, amino, (1-4C)alkylamino and (

A redox-sensitive resin linker for the solid phase synthesis of C- terminal modified peptides

With the rapid development of combinatorial chemistry using solid phase synthesis, there is a great deal of interest in developing new solid phase linkers, which are stable during the solid phase synthesis process and yet readily cleavable under mild conditions. By taking advantage of a 'trimethyl lock'-facilitated lactonization reaction, we have developed a redox-sensitive resin linker for the synthesis of C-terminal-modified peptides. The cleavage only requires mild reducing agents such as sodium hydrosulfite, which is not expected to cause any problem with the commonly seen organic functional groups. Using this new linker, three short peptides were synthesized with high isolated yields (70-90%). Such a linker could potentially be used for the synthesis of modified peptide libraries, which allows for the ready cleavage of the linker under mild conditions.