219943-61-0 Usage
Description
4-BROMO-D-TRYPTOPHAN is a chemical compound derived from the tryptophan family, an essential amino acid. It is a tryptophan derivative with a bromine atom attached to the fourth position of the benzene ring, exhibiting potential pharmacological applications, particularly in neuroscience and drug development.
Uses
Used in Pharmaceutical Industry:
4-BROMO-D-TRYPTOPHAN is used as a neuroprotective agent for its potential to protect neurons from damage and degeneration, which is crucial in treating various neurological disorders.
Used in Antidepressant Drug Development:
4-BROMO-D-TRYPTOPHAN is utilized as a precursor in the development of antidepressant medications due to its demonstrated effects on mood regulation and alleviation of depressive symptoms.
Used in Neuroscience Research:
4-BROMO-D-TRYPTOPHAN serves as a valuable tool in neuroscience research, aiding in the study of neurotransmitter systems and the exploration of novel therapeutic approaches for neurological conditions.
Used in Synthesis of Bioactive Compounds:
4-BROMO-D-TRYPTOPHAN is employed as a building block in the synthesis of bioactive compounds, contributing to the creation of new pharmaceuticals with potential applications in various medical fields.
Check Digit Verification of cas no
The CAS Registry Mumber 219943-61-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,9,9,4 and 3 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 219943-61:
(8*2)+(7*1)+(6*9)+(5*9)+(4*4)+(3*3)+(2*6)+(1*1)=160
160 % 10 = 0
So 219943-61-0 is a valid CAS Registry Number.
219943-61-0Relevant articles and documents
General synthesis of unnatural 4-, 5-, 6-, and 7-bromo-D-tryptophans by means of a regioselective indole alkylation
Bartoccini, Francesca,Fanini, Fabiola,Retini, Michele,Piersanti, Giovanni
, (2020)
A general two-step approach to enantiopure bromotryptophans from unprotected bromoindoles has been developed. Indole nucleophiles prepared with MeMgCl in the presence of CuCl reacted with cyclic sulfamidates derived from enantiopure D-serine to form 4-, 5-, 6-, or 7-bromo-D-tryptophan and some other halogenated tryptophans in moderate yields but with complete regioselectivity. The bromotryptophan derivatives were deprotected using mild conditions.
Enantiospecific synthesis of (r)-4-amino-5-oxo-1,3,4,5- tetrahydrobenz[cd]indole, an advanced intermediate containing the tricyclic core of the ergots
Hurt, Clarence R.,Lin, Ronghui,Rapoport, Henry
, p. 225 - 233 (2007/10/03)
We report a new strategy for the enantiospecific synthesis of (R)-4- amino-5-oxo-1,3,4,5-tetrahydrobenz[cd]indole. This compound is an advanced intermediate which contains the tricyclic core of many of the tetracyclic ergot alkaloids. Our method involves the initial synthesis of D-4- bromotryptophan from the coupling of an indolyllithium species with a masked serinal. The α-amino position was protected with an N-trityl group, ensuring the enantiomeric integrity of this position during the ensuing organometallic cyclization reaction. Stabilization of the tricycle was accomplished by protecting the indole nitrogen with a BOC group or by reducing the α-amino ketone to the corresponding β-amino alcohol.
