219963-52-7Relevant academic research and scientific papers
Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists: Identification of N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134)
Bromidge, Steven M.,Clarke, Stephen E.,Gager, Tracey,Griffith, Kerry,Jeffrey, Phillip,Jennings, Andrew J.,Joiner, Graham F.,King, Frank D.,Lovell, Peter J.,Moss, Stephen F.,Newman, Helen,Riley, Graham,Rogers, Derek,Routledge, Carol,Serafinowska, Halina,Smith, Douglas R.
, p. 55 - 58 (2007/10/03)
Substituted N-phenyl-4-methoxy-3-piperazin-1-ylbenzenesulfonamides and conformationally restricted analogues have been identified as high affinity and selective 5-HT6 antagonists. Compounds from this series had a range of pharmacokinetic profiles in rat and in general there was a correlation between clearance and CNS penetration. Based on its overall biological profile 2 (SB-357134) was selected for further pre-clinical evaluation. (C) 2000 Elsevier Science Ltd.
