219963-62-9Relevant academic research and scientific papers
Synthesis of 2 - halo - 3 - [...] borate - 5 - chloroaniline method
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Paragraph 0029; 0030; 0031, (2018/04/20)
The invention discloses a method for synthesizing 2-halogenated-3-pinacol borate-5-chloroaniline and belongs to the field of drug intermediate synthesis. The 2-halogenated-3-pinacol borate-5-chloroaniline is synthesized from 2-halogenated-5-chloro-nitrobenzene, which is used as a raw material and can be provided by the market through three steps of bromization, coupling and reduction; the method provided by the invention is faster in synthesis, simple and effective, and high in yield, and meanwhile, a coarse product obtained in each step can be directly used in the next step; since compared with an amino group, the nitro group is a strong electron withdrawing group, a method that coupling is performed and then reduction is performed in reaction is adopted, and the dosage of a catalyst can be reduced to 1-2 mol% in the second step of coupling, therefore, the reaction cost is further reduced.
PROCESS FOR THE PREPARATION OF ORGANIC HALIDES
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Paragraph 00122, (2017/08/01)
The present invention provides a halo-de-carboxylation process for the preparation of organic chlorides, organic bromides and mixtures thereof, from their corresponding carboxylic acids, using a chlorinating agent selected from trichloroisocyanuric acid (TCCA), dichloroisocyanuric acid (DCCA), or combination thereof, and a brominating agent.
Compounds and Compositions as Protein Kinase Inhibitors
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, (2011/04/14)
The present invention provides compounds of Formula I or II: wherein R1, R1b, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds of Formula (I) or (II) and pharmaceutical compositions thereof are useful for the treatment of B-Raf-associated diseases.
