219982-03-3Relevant academic research and scientific papers
Application of Baylis-Hillman methodology in a novel synthesis of quinoline derivatives
Familoni, Oluwole B.,Kaye, Perry T.,Klaas, Phindile J.
, p. 2563 - 2564 (1998)
Reaction of 2-nitrobenzaldehyde with vinyl carbonyl compounds in the presence of 1,4-diazabicyclo[2.2.2]octane affords Baylis-Hillman products, catalytic reduction of which results in direct cyclisation to quinoline derivatives.
The Baylis-Hillman approach to quinoline derivatives
Familoni, Oluwole B.,Klaas, Phindile J.,Lobb, Kevin A.,Pakade, Vusumzi E.,Kaye, Perry T.
, p. 3960 - 3965 (2008/09/18)
Baylis-Hillman reactions of 2-nitrobenzaldehydes with various activated alkenes afford adducts that undergo reductive cyclisation to quinoline derivatives. The chemo- and regioselectivity of cyclisation appears to be influenced by the choice of both the substrate and the reagent system, and competing reactions have been observed. The Royal Society of Chemistry 2006.
