219986-60-4

Basic information

• Product Name: 3-(4-bromo-phenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydro-pyrazole-1-carbothioic acid amide
• Synonyms: 3-(4-bromo-phenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydro-pyrazole-1-carbothioic acid amide
• CAS NO: 219986-60-4
• Molecular Weight: 368.177
• Mol File: 219986-60-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-(4-bromo-phenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydro-pyrazole-1-carbothioic acid amide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-bromo-phenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydro-pyrazole-1-carbothioic acid amide(219986-60-4)
• EPA Substance Registry System: 3-(4-bromo-phenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydro-pyrazole-1-carbothioic acid amide(219986-60-4)

Safety Data

• Hazardous Substances Data: 219986-60-4(Hazardous Substances Data)

Upstream product

• 79-19-6 thiosemicarbazide 
• 18931-61-8 4,4,4-trifluoro-1-(4-bromophenyl)butane-1,3-dione 

Downstream Products

• 1430228-89-9 2-(3-(4-bromophenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydropyrazol-1-yl)-4-(6-chlorocoumarin-3-yl)thiazole 
• 1430228-90-2 2-(3-(4-Bromophenyl)-5-hydroxy-5-trifluoromethyl-4,5-dih-ydropyrazol-1-yl)-4-(6-bromo-coumarin-3-yl)thiazole 
• 1430228-87-7 2-(3-(4-bromophenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydropyrazol-1-yl)-4-(coumarin-3-yl)thiazole 
• 219986-65-9 3-(4-bromophenyl)-5-(trifluoromethyl)-1H-pyrazole 

Relevant articles and documents

Synthesis and pharmacological evaluation of some novel 2-(5-hydroxy-5- trifluoromethyl-4,5-dihydropyrazol-1-yl)-4-(coumarin-3-yl)thiazoles

A series of novel 2-(5-hydroxy-5-trifluoromethyl-4,5-dihydropyrazol-1-yl)- 4-(coumarin-3-yl)thiazoles (6) were synthesized by condensing 3-(2-bromoacetyl)coumarins (4) with various 5-hydroxy-5-trifluoromethyl-4,5- dihydropyrazol-1-thiocarboxamides (5), obtained by the reaction of thiosemicarbazide with trifluoromethyl-β-diketones. All the tested compounds displayed significant to moderate in vivo anti-inflammatory activity when compared to the standard drug indomethacin, and good broad spectrum in vitro antibacterial activity against three Gram-positive and four Gram-negative bacteria when compared with cefixime.

Haloacetylated enol ethers 10. Condensation of β-alkoxyvinyl trifluoromethyl ketones with thiosemicarbazide. Synthesis of new trifluoromethyl 4,5-dihydro-1H-1-pyrazolethiocarboxyamides

The synthesis of 3-aryl[alkyl]-5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-1- pyrazolethiocarboxyamides (2a-g) from the direct cyclo-condensation reaction of β-alkoxyvinyl trifluoromethyl ketones (1a-g) with thiosemicarbazide in methanol, under mild conditions, is reported. Similarly, the 1H-1-pyrazolethiocarboxyamide derivatives (2a-g) were easily dehydrated and the thiocarboxyamide group hydrolyzed in a one-step reaction by stirring with concentrated sulfuric acid to give the 3-aryl[alkyl]-5-trifluoromethyl-1H-pyrazoles (3a-g) in good yields. Specific syntheses and physical properties of 3-aryl[alkyl]-5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-1- pyrazolethiocarboxyamides are reported here for the first time.