22002-17-1

Usage

InChI:InChI=1/C7H6Cl2O2/c8-5-1-4(3-10)2-6(9)7(5)11/h1-2,10-11H,3H2

Upstream product

• 79817-04-2 (3,5-dichloro-4-hydroxybenzyl)pyridinium chloride 
• 3337-59-5 methyl 3,5-dichloro-4-hydroxybenzoate 
• 3336-41-2 3,5-dichloro-4-hydroxybenzoic acid 
• 17302-82-8 ethyl 3,5-dichloro-4-hydroxybenzoate 
• 2314-36-5 3,5-dichloro-4-hydroxybenzaldehyde 
• 50-00-0 formaldehyd 
• 87-65-0 2,6-Dichlorophenol 
• 857537-88-3 4-acetoxy-3,5-dichloro-benzoic acid ethyl ester 

Downstream Products

• 3933-88-8 3,3',5,5'-Tetrachlor-4,4'-dihydroxydiphenylmethan 
• 2314-36-5 3,5-dichloro-4-hydroxybenzaldehyde 
• 158692-34-3 ethyl 2-(2,6-dichloro-4-hydroxymethylphenoxy)-2-(3,4-methylenedioxyphenyl) acetate 
• 76890-93-2 4,4’-dihydroxydibenzyl ether 
• 73049-09-9 1-(3,5-dichloro-4-hydroxyphenyl)-2-phenylethanol 
• 73048-86-9 benzyl 3,5-dichloro-4-hydroxyphenyl ketone 
• 85628-62-2 3,5-Dichlor-4-methoxy-(2-amino-2-methylpropyl)benzol 
• 85628-51-9 3,5-Dichlor-4-methoxy-(2-methyl-2-nitropropyl)benzol 
• 85628-57-5 2,6-Dichlor-4-(2-amino-2-methylpropyl)phenol 
• 212067-18-0 (R,S)-N-acetyl-α-(3,5-dichloro-4-hydroxyphenyl)glycine 
• 85628-45-1 2,6-Dichlor-4-(2-methyl-2-nitropropyl)phenol 
• 55008-59-8 bis-(3,5-dichloro-4-hydroxy-benzyl)-ether 

Relevant academic research and scientific papers

CLASS OF BIFUNCTIONAL COMPOUNDS WITH QUATERNARY AMMONIUM SALT STRUCTURE

The invention provides a class of compounds represented by formula (I), having bifunctional active quaternary ammonium salt structure of a β2-adrenoreceptor agonist and an M receptor antagonist, a pharmaceutically acceptable salt, solvate, and optical isomer thereof. A pharmaceutical composition comprising such a compound with quaternary ammonium salt structure, a method for preparing such a compound with quaternary ammonium salt structure and an intermediate thereof, and uses thereof in treating pulmonary disorders are also provided. The compounds of the invention have high selectivity to the M receptor subtype, and have less adverse reaction and lower toxic and side effects in the treatment of pulmonary diseases such as COPD and asthma.

Primary Amines as Renin Inhibitors

The invention relates to novel primary amine derivatives and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.

BICYCLONONENE DERIVATIVES AS RENIN INHIBITORS

The invention relates to novel bicyclononene derivatives of Formula (I); and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.

BICYLONONENE DERIVATIVES

The invention relates to bicyclononene derivatives and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.

BICYCLIC FIVE-MEMBERED HETEROARYL DERIVATIVES AND THEIR USE AS RENIN INHIBITORS

The invention relates to novel five-membered heteroaryl derivatives and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions comprising one or more of those compounds and especially their use as inhibitors of renin.

Novel imidazole derivatives with anti-inflammatory activity

Novel imidazole derivatives of formula I and their salts, solvates and prodrugs, wherein the meanings of the different radicals are as shown in the description. Said compounds are useful as anti-inflammatory agents.

SIX MEMBERED RING FUSED IMIDAZOLES SUBSTITUTED WITH PHENOXYPHENYLACETIC ACID DERIVATIVES USED TO TREAT ASTHMA

Phenoxyphenylacetic acids and derivatives of general structural formula I STR1 have endothelin antagonist activity and are therefore useful in treating cardiovascular disorders, such as hypertension, congestive heart failure, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, inflammatory diseases, Raynaud's disease, and endotoxic shock, and asthma.

ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED PYRIDOIMIDAZOLYL RING

Substituted heterocycles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I are useful as angiotensin II antagonists. STR1