220062-99-7

Upstream product

• 220062-98-6 N-{2-chloro-4-fluoro-5-[4-(2-fluoro-ethyl)-3-methyl-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-phenyl}-methanesulfonamide 
• 74-88-4 methyl iodide 
• 111992-04-2 4,5-dihydro-1-(4-chloro-2-fluorophenyl)-3-methyl-5-oxo-1H-1,2,4-triazole 
• 220062-95-3 2-(4-chloro-2-fluoro-phenyl)-4-(2-fluoro-ethyl)-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one 
• 220062-97-5 1-(4-chloro-2-fluoro-5-aminophenyl)-4-(2-fluoroethyl)-4,5-dihydro-3-methyl-1,2,4-triazolin-5(1H)-one 
• 220062-96-4 2-(4-chloro-2-fluoro-5-nitro-phenyl)-4-(2-fluoro-ethyl)-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one 

Downstream Products

• 220063-00-3 N-{5-[4-(2-bromo-ethyl)-3-methyl-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-2-chloro-4-fluoro-phenyl}-N-methyl-methanesulfonamide 
• 220063-01-4 N-[2-chloro-4-fluoro-5-(3-methyl-5-oxo-4-vinyl-4,5-dihydro-[1,2,4]triazol-1-yl)-phenyl]-N-methyl-methanesulfonamide 

Relevant academic research and scientific papers

Novel applications of alkyl fluorides in organic synthesis: Versatile nitrogen protecting groups

The potential of the 2-fluoroethyl group as a nitrogen protecting group was demonstrated. The stability of alkyl fluorides, such as 2-fluoroethyl, to a variety of reaction conditions, makes them attractive nitrogen protecting groups. The 2-fluoroethyl group was easily introduced, in good yields, by the treatment of the NH group with potassium carbonate and 2-bromo-1- fluoroethane. Reaction of the 2-fluoroethyl group with boron tribromide resulted in the replacement of fluorine by bromine, to give the corresponding 2-bromoethyl group which was easily removed by known methods.