220096-05-9

Upstream product

• 55136-47-5 3-((S)-Amino-carboxy-methyl)-benzoic acid 
• 220096-06-0 3-[(S)-Cyano-((R)-2-hydroxy-1-phenyl-ethylamino)-methyl]-benzonitrile 
• 24964-64-5 3-Cyanobenzaldehyde 
• 147150-01-4 4-(2-Amino-6-methyl-4-oxo-3,4-dihydro-quinazolin-5-ylsulfanyl)-benzoic acid 
• 220096-02-6 3-((S)-Amino-methoxycarbonyl-methyl)-benzoic acid methyl ester 

Relevant academic research and scientific papers

Synthesis of 5-substituted quinazolinone derivatives and their inhibitory activity in vitro

Quinazolinone derivatives I and their methyl esters were synthesized and evaluated as nonclassical lipophilic inhibitors of thymidylate synthase. Compounds Ib and Ic containing OH and CO2H as R substituents, respectively, were most effective, indicating that hydrogen bonding may contribute to the increased inhibitory activity. These compounds further showed high cytotoxic activity against tumor cells in culture.