2201-42-5 Usage
General Description
1-(1-phenylcyclohexyl)-4-methylpiperidine is a chemical compound with the molecular formula C18H27N. It is also known as PCMP and is a derivative of the psychoactive drug phencyclidine (PCP). PCMP is a potent dissociative anesthetic that acts as a NMDA receptor antagonist, similar to PCP. It is classified as a designer drug and has been reported as a recreational drug, with effects including hallucinations, euphoria, and dissociation from reality. However, PCMP has been associated with a range of adverse effects, including neurotoxicity, and has been banned in some countries. Due to its potential for misuse and harm, PCMP is a controlled substance in many jurisdictions.
Check Digit Verification of cas no
The CAS Registry Mumber 2201-42-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,2,0 and 1 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 2201-42:
(6*2)+(5*2)+(4*0)+(3*1)+(2*4)+(1*2)=35
35 % 10 = 5
So 2201-42-5 is a valid CAS Registry Number.
InChI:InChI=1/C18H27N.ClH/c1-16-10-14-19(15-11-16)18(12-6-3-7-13-18)17-8-4-2-5-9-17;/h2,4-5,8-9,16H,3,6-7,10-15H2,1H3;1H
2201-42-5Relevant articles and documents
Synthesis and preliminary biochemical evaluation of novel derivatives of PCP
Linders, Joannes T. M.,Furlano, David C.,Mattson, Mariena V.,Jacobson, Arthur E.,Rice, Kenner C.
scheme or table, p. 79 - 87 (2011/01/13)
(±)-Trans-Ph/Et and (±)-cis-Ph/Et 1-(2-ethyl-1- phenylcyclohexyl)piperidine were synthesized from 2-ethylcyclohexanone. In contrast to the corresponding trans-substituted 2-methyl compound which is 5x more potent than PCP, the trans-2-ethyl derivative has a 75x lower affinity for the PCP binding site. The cis-2-ethyl isomer is inactive like the cis-2-methyl derivative. (±)-1-(1-Phenylcyclohexyl)-2-methylpiperidine is almost as active as the parent PCP. Reduction of the aromatic ring or quaternization of the piperidine in PCP reduces the affinity for the PCP site.
