220108-54-3

Usage

Uses

Used in Chemical Synthesis:
2-[4-(R)-phenyl-4,5-dihydrooxazolin-2-yl]quinoline is used as a chiral ligand for the enantioselective diamination of alkenes. Its unique structure allows for the selective formation of specific enantiomers, which is crucial in the synthesis of chiral compounds with desired biological activities.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-[4-(R)-phenyl-4,5-dihydrooxazolin-2-yl]quinoline is used as a key component in the development of novel drugs. Its chiral nature enables the creation of enantiomerically pure compounds, which can have significant implications for drug efficacy and safety.
Used in Catalyst Development:
2-[4-(R)-phenyl-4,5-dihydrooxazolin-2-yl]quinoline is also utilized in the development of new catalysts for various chemical reactions. Its chiral properties make it a valuable asset in designing catalysts that can selectively promote specific reactions, leading to more efficient and environmentally friendly processes.

Upstream product

• 1436-43-7 quinoline-2-carbonitrile 
• 56613-80-0 D-2-phenylglycinol 
• 50342-01-3 quinolin-2-ylcarbonyl chloride 
• 93-10-7 quinoline-2-carboxylic acid 

Relevant academic research and scientific papers

Pyridine-oxazoline and quinoline-oxazoline ligated cobalt complexes: Synthesis, characterization, and 1,3-butadiene polymerization behaviors

A series of cobalt complexes supported by pyridine-oxazoline (Pyox) and quinoline-oxazoline (Quox) were synthesized. Determined by single crystal X-ray crystallography, complexes 6a and 7c adopted distorted octahedron and trigonal bipyramid geometries, re

Pd-catalyzed asymmetric aza-Wacker-type cyclization reaction of olefinic tosylamides

The Pd-catalyzed asymmetric aza-Wacker-type cyclization reaction of the olefinic tosylamides with molecular oxygen as the green oxidant was developed. Under the optimized conditions, excellent catalytic activity and good enantioselectivity with up to 74%

Palladium(II)-catalyzed enantioselective aerobic dialkoxylation of 2-propenyl phenols: A pronounced effect of copper additives on enantioselectivity

A direct O2-coupled Pd(II)-catalyzed enantioselective dialkoxylation of 2-propenylphenols has been developed by utilizing chiral quinoline oxazoline ligands. A detrimental effect of added copper salts on enantioselectivity was observed which is attributed to the displacement of the chiral ligand off of Pd(II). Copyright

Steric effects of the ligand in the enantioselective palladium-catalyzed allylic alkylation using chiral oxazolinylpyridines

Eight new chiral oxazolinylpyridines were prepared and assessed in the enantioselective palladium-catalyzed allylic substitution of 1,3- diphenylprop-2-enyl acetate with dimethyl malonate. Catalytic activity and enantioselectivity were found to be highly

Palladium-catalyzed allylic alkylation using pyridino-oxazolines and quinolino-oxazolines as ligands - Influence of steric factors

Four new chiral pyridino- and quinolino-oxazolines were subjected to the palladium-catalyzed alkylation of 1,3-diphenyl-2-propenyl acetate. The enantioselectivity varied (82-88% ee) with the steric properties of the ligands. The results are discussed in connection with results previously obtained using analogous ligands.