220114-73-8Relevant articles and documents
Novel B-ring modified combretastatin analogues: Syntheses and antineoplastic activity
Hatanaka, Toshihiro,Fujita, Koichi,Ohsumi, Koji,Nakagawa, Ryusuke,Fukuda, Yumiko,Nihei, Yukio,Suga, Yasuyo,Akiyama, Yukio,Tsuji, Takashi
, p. 3371 - 3374 (2007/10/03)
A series of B-ring modified combretastatin analogues were synthesized and their inhibitory activity against microtubule assembly, cytotoxic activity against Colon 26 adenocarcinoma cancer cell line were evaluated. Among these, pyridone derivative (19) showed strong antimitotic activity and cytotoxicity, along with excellent water-solubility.