220115-22-0Relevant academic research and scientific papers
Resistance-modifying agents. 5.1 Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP)
Griffin, Roger J.,Srinivasan, Sheila,Bowman, Karen
, p. 5247 - 5256 (1998)
Clinical studies concerning the role of poly(ADP-ribose) polymerase (PARP) in the repair of drug- and radiation-induced DNA damage have been impeded by the poor solubility, lack of potency, and limited specificity of currently available inhibitors. A seri
