220115-72-0

Basic information

• Product Name: METHYL-N-BOC-4[(DIETHOXY-PHOSPHORYL)-DIFLUORO]METHYL PHENYLALANINE
• CAS NO: 220115-72-0
• Molecular Formula: C₁₆H₃₂O₆Si
• Molecular Weight: 0
• Mol File: 220115-72-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 544.9°C at 760 mmHg
• Flash Point: 283.4°C
• Appearance: /
• Density: 1.209g/cm³
• Vapor Pressure: 6.22E-12mmHg at 25°C
• Refractive Index: 1.478
• CAS DataBase Reference: METHYL-N-BOC-4[(DIETHOXY-PHOSPHORYL)-DIFLUORO]METHYL PHENYLALANINE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL-N-BOC-4[(DIETHOXY-PHOSPHORYL)-DIFLUORO]METHYL PHENYLALANINE(220115-72-0)
• EPA Substance Registry System: METHYL-N-BOC-4[(DIETHOXY-PHOSPHORYL)-DIFLUORO]METHYL PHENYLALANINE(220115-72-0)

Safety Data

• Hazardous Substances Data: 220115-72-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C20H30F2NO7P/c1-7-28-31(26,29-8-2)20(21,22)15-11-9-14(10-12-15)13-16(17(24)27-6)23-18(25)30-19(3,4)5/h9-12,16H,7-8,13H2,1-6H3,(H,23,25)

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 63167-69-1 methyl 2,3-O-isopropylidene-α-D-mannopyranoside 

Downstream Products

• 484000-91-1 methyl 6-O-(tert-butyldimethylsilyl)-4-O-(2-bromo-5-methoxybenzyl)-2,3-O-isopropylidene-α-D-mannopyranoside 
• 1380778-47-1 C₁₇H₂₁N₃O₆ 
• 1380778-50-6 methyl 4-O-(2-azidobenzyl)-5-ethynyl-2,3-O-isopropylidene-α-D-mannopyranoside 
• 1380778-44-8 methyl 4-O-(2-azidobenzyl)-2,3-O-isopropylidene-α-D-mannopyranoside 
• 1380778-41-5 methyl 4-O-(2-azidobenzyl)-6-O-(tert-butyldimethylsilyl)-2,3-O-isopropylidene-α-D-mannopyranoside 
• 484000-96-6 [(3aS,4S,6R,7R,7aS)-7-(2-Bromo-4,5-dimethoxy-benzyloxy)-4-methoxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yl]-methanol 
• 484000-95-5 (3aS,4S,6R,7R,7aS)-[7-(2-bromo-5-methoxybenzyloxy)-4-methoxy-2,2-dimethyltetrahydro-2H,4H-[1,3]dioxolo[4,5-c]pyran-6-yl]methanol 
• 484001-00-5 (3aS,4S,6S,7S,7aS)-7-(2-Bromo-4,5-dimethoxy-benzyloxy)-4-methoxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-carbaldehyde 
• 484001-03-8 (3aS,4S,6R,7R,7aS)-7-(2-Bromo-5-methoxy-benzyloxy)-4-methoxy-2,2-dimethyl-6-vinyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran 
• 484000-99-9 (3aS,4S,6S,7S,7aS)-7-(2-Bromo-5-methoxy-benzyloxy)-4-methoxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-carbaldehyde 
• 484000-94-4 (3aS,4S,6R,7R,7aS)-[7-(2-bromobenzyloxy)-4-methoxy-2,2-dimethyltetrahydro-2H,4H-[1,3]dioxolo[4,5-c]pyran-6-yl]methanol 
• 484001-02-7 (3aS,4S,6R,7R,7aS)-7-(2-Bromo-benzyloxy)-4-methoxy-2,2-dimethyl-6-vinyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran 
• 484000-98-8 (3aS,4S,6S,7S,7aS)-7-(2-Bromo-benzyloxy)-4-methoxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-carbaldehyde 
• 484000-90-0 methyl 6-O-(tert-butyldimethylsilyl)-4-O-(2-bromobenzyl)-2,3-O-isopropylidene-α-D-mannopyranoside 

Relevant articles and documents

Palladium-catalyzed intramolecular C-O bond formation: An approach to the synthesis of chiral benzodioxocines

Palladium-catalyzed intramolecular aryl etherification using bulky binaphthylphosphane or bis(diphenylphosphanyl)ferrocene ligands is shown to be a convenient method for the synthesis of eight-membered oxygen heterocycles. Application of this methodology to a sugar derivative led to the synthesis of chiral benzodioxocine. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.

Preparation of cyclic peptide antifungal agents

The present invention provides phosphonylating agents and phosphonylation conditions that are compatible with the acid- and base-sensitive compounds and which promote a regioselective and reproducible conversion to a phosphonate compound. Also provided are intermediates that may be used to prepare phosphonate derivatives of cyclic peptides antifungal agent and a process for converting the phosphonates to the desired phosphonic acid prodrugs.