220153-09-3Relevant academic research and scientific papers
Novel synthesis of enantiomerically pure natural inositols and their diastereomers
Takahashi, Hideyo,Kittaka, Hisae,Ikegami, Shiro
, p. 9707 - 9710 (2007/10/03)
A novel synthesis of all stereoisomers of natural inositols has been developed. The key strategy is the stereoselective reduction of substituted β-hydroxy cyclohexanones which are prepared from a variety of 6-O-acetyl 5- enopyranosides via Ferrier-II reaction catalyzed by palladium chloride. The utility of this approach is demonstrated by the synthesis of D-myo-inositol 1,4,5-tris(phosphate)(IP3).
