220166-23-4

Upstream product

• 773-64-8 2-mesitylenesulphonyl chloride 
• 95-54-5 1,2-diamino-benzene 

Downstream Products

• 220165-50-4 1,4-ditosyl-2-vinyl-1,2,3,4-tetrahydroquinoxaline 
• 220167-11-3 1,2,3,4-tetrahydro-2-vinylquinoxaline 
• 49633-27-4 2-hydroxymethyl-1,4-bis-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-quinoxaline 

Relevant academic research and scientific papers

A Versatile Synthesis of Vinyl-Substituted Heterocycles via Regio- And Enantioselective Pd-Catalyzed Tandem Allylic Substitution

We herein report a versatile, regio- and enantioselective palladium-catalyzed tandem allylic substitution powered by a chiral bisphosphorus ligand WingPhos with the palladium loading as low as 0.1 mol %, forming a series of chiral vinyl-substituted heterocycles, including tetrahydroquinoxalines, piperazines, dihydro-2H-benzo[b][1,4]-oxazines, and morpholines, in exellent ee's and yields. The protocol features readily available starting materials, mild reaction conditions, and a broad substrate scope. Mechanistic investigation supports a tandem allylic substitution process.