220175-92-8Relevant academic research and scientific papers
Substrate evaluation of rhodococcus erythropolis SET1, a nitrile hydrolysing bacterium, demonstrating dual activity strongly dependent on nitrile sub-structure
Coady, Tracey M.,Coffey, Lee V.,O'Reilly, Catherine,Lennon, Claire M.
, p. 1108 - 1116 (2015)
Assessment of Rhodococcus erythropolis SET1, a novel nitrile hydrolysing bacterial isolate, has been undertaken with 34 nitriles, 33 chiral and 1 prochiral. These substrates consist primarily of β-hydroxy nitriles with varying alkyl and aryl groups at the β position and containing in several compounds different substituents α to the nitrile. In the case of β-hydroxy nitriles without substitution at the α position, acids were the major products obtained, along with recovered nitrile after biotransformation, as a result of suspected nitrilase activity of the isolate. Unexpectedly, amides were found to be the major hydrolysis product when the β-hydroxy nitriles possessed a vinyl group at this position. To probe this behaviour further, additional related substrates were evaluated containing electron-withdrawing groups at the α position, and amide was also observed upon biotransformation in the presence of SET1. Therefore this novel isolate has also demonstrated NHase activity with nitriles that appears to be substrate-dependent.
Design, synthesis, and biological evaluation of 4-H pyran derivatives as antimicrobial and anticancer agents
Reddy, Thatikonda Narendar,Ravinder, Mettu,Bikshapathi, Raktani,Sujitha, Pombala,Kumar, C. Ganesh,Rao, Vaidya Jayathirtha
, p. 2832 - 2844 (2017/10/06)
A series of pyran derivatives (5–27) were synthesized in good yields by utilizing Baylis–Hillman chemistry and were further investigated for their in vitro anticancer, antibacterial, and antifungal activities. Most of the tested compounds exhibited promis
Electrophilic warhead-based design of compounds preventing NLRP3 inflammasome-dependent pyroptosis
Cocco, Mattia,Garella, Davide,Di Stilo, Antonella,Borretto, Emily,Stevanato, Livio,Giorgis, Marta,Marini, Elisabetta,Fantozzi, Roberto,Miglio, Gianluca,Bertinaria, Massimo
, p. 10366 - 10382 (2015/02/19)
Pyroptosis is a caspase-1-dependent pro-inflammatory form of programmed cell death implicated in the pathogenesis of autoinflammatory diseases as well as in disorders characterized by excessive cell death and inflammation. Activation of NLRP3 inflammasome
Synthesis of substituted 3-methylene-2-pyridones from Baylis-Hillman derivatives and its application for the generation of 2-pyridone substituted spiroisoxazolines
Singh, Virender,Yadav, Gaya P.,Maulik, Prakas R.,Batra, Sanjay
, p. 2979 - 2991 (2008/09/19)
The synthesis of substituted 3-methylene-2-pyridones via SN2 displacement reaction of nucleophiles bearing a keto group on the acetyl derivative of Baylis-Hillman adducts of acrylonitrile followed by TFA/H2SO4-mediated int
