2201839-83-8

Basic information

• Product Name: 4-(2-acetyl-5-chlorophenyl)-5-methoxypyridine-2(1H)-one
• CAS NO: 2201839-83-8
• Molecular Weight: 277.707
• Mol File: 2201839-83-8.mol

Chemical Properties

• CAS DataBase Reference: 4-(2-acetyl-5-chlorophenyl)-5-methoxypyridine-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-acetyl-5-chlorophenyl)-5-methoxypyridine-2(1H)-one(2201839-83-8)
• EPA Substance Registry System: 4-(2-acetyl-5-chlorophenyl)-5-methoxypyridine-2(1H)-one(2201839-83-8)

Safety Data

• Hazardous Substances Data: 2201839-83-8(Hazardous Substances Data)

Usage

Structure

A pyridinone derivative with a substituted phenyl and acetyl group

Common Use

Building block in the synthesis of various drugs in the pharmaceutical industry

Therapeutic Properties

Potential antimicrobial and anti-inflammatory effects

Significance

Valuable component in drug discovery and development due to its chemical structure and properties

Upstream product

• 867267-24-1 2,5-dimethoxypyridine 
• 1630193-77-9 (2,5-dimethoxypyridin-4-yl)boronic acid 
• 825-40-1 2-bromo-p-chloroacetophenone 

Relevant articles and documents

Medicine purpose of FXIa inhibitor compound or salt thereof

The invention belongs to the technical field of medicines, provides a medicine purpose of a FXIa inhibitor compound or salt thereof, and particularly relates to the purpose of the FXIa inhibitor compound or the salt thereof in preparation of medicines use

CRYSTAL FORM OF OXOPICOLINAMIDE DERIVATIVE AND PREPARATION METHOD THEREFOR

Provided are a crystal form of an oxopicolinamide derivative and a preparation method therefor. In particular, provided are crystal forms A, B, C, D, E, and F of a compound as shown in formula (I) and a preparation method therefor. Crystal forms A, B, C, D, E, and F of the compound of formula (I) obtained in the present disclosure have good crystal stability and chemical stability, and can be better used in clinical treatment.

Pharmaceutically acceptable salt of oxopyridine amide derivatives and preparation method of same

The invention belongs to the technical field of medicine preparation, and particularly relates to pharmaceutically acceptable salt of oxopyridine amide derivatives and a preparation method of the same. The invention particularly provides the pharmaceutically acceptable salts of (S)-4-(2-(4-(2-acetyl-5-chlorophenyl)-5-methoxy-2-oxopyridine-1-(2H)-yl)-3-phenylpropionylamino) benzoic acid (Formula I), including addition salts thereof with acids or bases, as well as pharmaceutical compositions containing the salts and pharmaceutical uses of the salts.

OXOPICOLINAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF

The present invention relates to an oxopicolinamide derivative, a preparation method therefor and the pharmaceutical use thereof. In particular, the present invention relates to the oxopicolinamide derivative as shown in the general formula (AI), a preparation method therefor and a pharmaceutical composition comprising the derivative, and to the use thereof as a therapeutic agent, in particular as an inhibitor of blood coagulation factor XIa (Factor XIa, FXIa for short) and the use thereof in the preparation of a drug for treating diseases such as thromboembolism, wherein the definition of each substituent in the general formula (AI) is the same as defined in the description.

Pharmaceutical composition of oxopicolinamide derivatives and preparing method thereof

The invention relates to a pharmaceutical composition of oxopicolinamide derivatives and a preparing method thereof. Specifically, the invention provides solid dispersion body preparations of (S)-4-(2-(4-(2-acetyl-5-chlorophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl)-3-phenylpropanamide)benzoic acid or medicinal salts thereof and a preparing method thereof. The drug composition prepared by the solid dispersion bodies has high release rate and bioavailability.