220191-03-7Relevant academic research and scientific papers
Identification of a novel, orally bioavailable histamine H3 receptor antagonist based on the 4-benzyl-(1H-imidazol-4-yl) template
Aslanian, Robert,Mutahi, Mwangi W.,Shih, Neng-Yang,McCormick, Kevin D.,Piwinski, John J.,Ting, Pauline C.,Albanese, Margaret M.,Berlin, Michael Y.,Zhu, Xiaohong,Wong, Shing-Chun,Rosenblum, Stuart B.,Jiang, Yueheng,West, Robert,She, Susan,Williams, Shirley M.,Bryant, Matthew,Hey, John A.
, p. 937 - 941 (2007/10/03)
A novel series of histamine H3 receptor antagonists, based on the 4-benzyl-(1H-imidazole-4-yl) template, incorporating urea and carbamate linkers has been prepared. Compound 3j is a selective H3 antagonist and demonstrates excellent
Substituted imidazole derivatives and their use as histamine H3 receptor ligands
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, (2008/06/13)
Compounds of formula (I) and their pharmaceutically acceptable salts are useful as histamine H3receptor ligands. R1and R3are optional substituents such as C1to C6alkyl. R2represents a bond
