220220-12-2

Upstream product

• 220220-32-6 tert-butyl 4-(4-{[(7-cyano-2-naphthyl)methyl]amino}phenyl)-1,4-diazepane-1-carboxylate 
• 220220-23-5 tert-butyl 4-(4-nitrophenyl)-1,4-diazepane-1-carboxylate 
• 441313-14-0 4-(4-aminophenyl)-[1,4]-diazepane-1-carboxylic acid tert-butyl ester 
• 112275-50-0 tert-butyl 1,4-diazepine-1-carboxylate 
• 220220-08-6 tert-butyl 4-{4-[[(7-cyano-2-napthyl)methyl](methylsulfonyl)amino]phenyl}-1,4-diazepane-1-carboxylate 

Relevant academic research and scientific papers

Synthesis and biological activity of novel 1,4-diazepane derivatives as factor Xa inhibitor with potent anticoagulant and antithrombotic activity

Factor Xa (fXa) is a serine protease involved in the coagulation cascade, which has received great interest as a potential target for the development of new antithrombotic drugs. Herein we report a novel series of fXa inhibitors in which the 1,4-diazepane moiety was designed to interact with the S4 aryl-binding domain of the fXa active site. Compound 13 (YM-96765) showed potent fXa inhibitory activity (IC50=6.8nM) and effective antithrombotic activity without prolonging bleeding time.