220239-64-5 Usage
Uses
Used in Pharmaceutical Industry:
2,4,6-Trifluorobenzenesulfonyl chloride is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to introduce the trifluoromethylsulfonyl group into organic molecules, enhancing their biological activity and pharmacological properties.
Used in Agrochemical Industry:
In the agrochemical industry, 2,4,6-trifluorobenzenesulfonyl chloride is utilized as a reagent in the production of agrochemicals, contributing to the development of more effective and targeted pesticides and other agricultural chemicals.
Used in Specialty Chemicals Production:
2,4,6-Trifluorobenzenesulfonyl chloride is employed as a building block in the synthesis of specialty chemicals, where its strong electrophilic nature allows for the creation of novel compounds with unique properties for various applications.
Safety Precautions:
Due to its high reactivity, 2,4,6-trifluorobenzenesulfonyl chloride should be handled with extreme caution. It can cause severe irritation to the eyes, skin, and respiratory system, necessitating proper safety measures during its use and storage.
Check Digit Verification of cas no
The CAS Registry Mumber 220239-64-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,0,2,3 and 9 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 220239-64:
(8*2)+(7*2)+(6*0)+(5*2)+(4*3)+(3*9)+(2*6)+(1*4)=95
95 % 10 = 5
So 220239-64-5 is a valid CAS Registry Number.
InChI:InChI=1/C6H2ClF3O2S/c7-13(11,12)6-4(9)1-3(8)2-5(6)10/h1-2H
220239-64-5Relevant academic research and scientific papers
Novel halogenated sulfonamides inhibit the growth of multidrug resistant MCF-7/ADR cancer cells
Medina, Julio C.,Roche, Daniel,Shan, Bei,Learned, R. Marc,Frankmoelle, Walter P.,Clark, David L.,Rosen, Terry,Jaen, Juan C.
, p. 1843 - 1846 (2007/10/03)
In this report, we describe the synthesis of halogenated benzenesulfonamide compounds and their ability to inhibit the growth of HeLa, MCF-7 and MCF-7/ADR tumor cells in vitro. The multidrug resistance (MDR) phenotype of certain cells does not affect their sensitivity to these compounds. These agents belong to a family of compounds previously shown to bind irreversibly to cysteine-239 of β-tubulin. Consistent with this mechanism of action, the cytotoxicities of these compounds appear to correlate with their ability to undergo nucleophilic aromatic substitution.
