220239-64-5 Usage
General Description
2,4,6-Trifluorobenzenesulfonyl chloride is a chemical compound with the formula C6H2ClF3O2S. It is a colorless to pale yellow liquid that is primarily used as a reagent in organic synthesis. 2,4,6-Trifluorobenzenesulfonyl chloride is an important building block for the production of pharmaceuticals, agrochemicals, and other specialty chemicals. It is known for its strong electrophilic properties and is commonly used to introduce the trifluoromethylsulfonyl group into various organic molecules. 2,4,6-TRIFLUOROBENZENESULFONYL CHLORIDE is highly reactive and should be handled with caution, as it can cause severe irritation to the eyes, skin, and respiratory system.
Check Digit Verification of cas no
The CAS Registry Mumber 220239-64-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,0,2,3 and 9 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 220239-64:
(8*2)+(7*2)+(6*0)+(5*2)+(4*3)+(3*9)+(2*6)+(1*4)=95
95 % 10 = 5
So 220239-64-5 is a valid CAS Registry Number.
InChI:InChI=1/C6H2ClF3O2S/c7-13(11,12)6-4(9)1-3(8)2-5(6)10/h1-2H
220239-64-5Relevant articles and documents
Novel halogenated sulfonamides inhibit the growth of multidrug resistant MCF-7/ADR cancer cells
Medina, Julio C.,Roche, Daniel,Shan, Bei,Learned, R. Marc,Frankmoelle, Walter P.,Clark, David L.,Rosen, Terry,Jaen, Juan C.
, p. 1843 - 1846 (2007/10/03)
In this report, we describe the synthesis of halogenated benzenesulfonamide compounds and their ability to inhibit the growth of HeLa, MCF-7 and MCF-7/ADR tumor cells in vitro. The multidrug resistance (MDR) phenotype of certain cells does not affect their sensitivity to these compounds. These agents belong to a family of compounds previously shown to bind irreversibly to cysteine-239 of β-tubulin. Consistent with this mechanism of action, the cytotoxicities of these compounds appear to correlate with their ability to undergo nucleophilic aromatic substitution.
