220256-41-7

Upstream product

• 220256-37-1 ethyl (4R,1'R)-[1-(1'-phenyleth-1'-yl)-2-oxopyrrolidin-4-yl]acetate 
• 220256-31-5 ethyl (3S,4S,1'R)-[1-(1'-phenyleth-1'-yl)-3-methoxycarbonyl-2-oxopyrrolidin-4-yl]acetate 

Downstream Products

• 220256-47-3 (4S,1'R)-1-(1'-phenyleth-1'-yl)-4-(2-iodoeth-1-yl)pyrrolidin-2-one 
• 220256-43-9 (4S,1'R)-1-(1'-phenyleth-1'-yl)-4-(2-methanesulfonyloxyeth-1-yl)pyrrolidin-2-one 

Relevant academic research and scientific papers

From pyrrolidin-2-ones to 3-aza-2-oxobicyclo[3.2.0]heptanes. Synthesis of both enantiomers of cis-2-aminomethylcyclobutane carboxylic acid, a conformationally restricted analogue of GABA

By changing the cyclisation conditions (NaH in THF or NaOEt in EtOH), an enantiopure malonamide containing an enoate acceptor afforded either diastereomeric pyrrolidin-2-one 3 or 4 as the major product of the intramolecular conjugate addition. After separ