220265-62-3Relevant academic research and scientific papers
Substituted indole compounds as anti-inflammatory and analgesic agents
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, (2008/06/13)
This invention provides a compound of the following formula: or the pharmaceutically acceptable salts thereof wherein R1is H or C1-4alkyl; R2is C(═L′)R3or So2R4; Y is a direct bond or C1-4alkylene; L and L′ are independently oxygen or sulfur; Q is selected from the following: C1-6alkyl, halo-substituted C1-4alkyl, optionally substituted C3-7cycloalkyl, optionally substituted phenyl or naphthyl, optionally substituted5or6-membered monocyclic aromatic group; R3is —OR6, —NR7R8, N(OR1)R7or a group of formula: Z is a direct bond, O, S or NR5; R4is C1-6alkyl, halo-substituted C1-4alkyl, optionally substituted phenyl or naphthyl; R5is C1-4alkyl or halo-substituted C1-4alkyl; R6is C1-4alkyl C3-7cycloalkyl, C1-4alkyl-C3-7cycloalkyl, halo-substituted C1-4alkyl, optionally substituted C1-4alkyl-phenyl or phenyl; R7and R8are each selected from the following: H, optionally substituted C1-6alkyl, optionally substituted C3-7cycloalkyl, optionally substituted C1-4alkyl-C3-7cycloalkyl, and optionally substituted C1-4alkyl-phenyl or phenyl; X is each selected from halo, C1-4alkyl, halo-substituted C1-4alkyl, OH, C1-4alkoxy, halo-substituted C1-4alkoxy, C1-4alkylthio, NO2, NH2, di-(C1-4alkyl)amino and CN; n is 0, 1, 2 or 3; and r is 1, 2 or 3. This invention also provides a pharmaceutical composition useful for the treatment of a medical condition in which prostaglandins are implicated as pathogens.
Indole compounds as COX-2 inhibitors
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, (2008/06/13)
This invention provides a compound of the following formula: and the pharmaceutically acceptable salts thereof, wherein L is oxygen or sulfur; Y is a direct bond or C1-4alkylidene; Q is C1-6alkyl, C3-7cycloalkyl, phenyl, naphthyl, heteroaryl or the like; R1is hydrogen, C1-6alkyl or the like; R2is hydrogen, C1-4alkyl, C(O)R5wherein R5is C1-22alkyl or C2-22alkenyl, halosubstituted C1-8alkyl, halosubstituted C2-8alkenyl, —Y—C3-7cycloalkyl, —Y—C3-7cycloalkenyl, phenyl, naphthyl, heteroaryl or the like; X is halo, C1-4alkyl, hydroxy, C1-4alkoxy or the like; and n is 0, 1, 2 or 3, with the proviso that a group of formula —Y—Q is not methyl or ethyl when X is hydrogen; L is oxygen; R1is hydrogen; and R2is acetyl. This invention also provides a pharmaceutical composition useful for the treatment of a medical condition in which prostaglandins are implicated as pathogens.
