220284-70-8

Basic information

• Product Name: 1-(3-Benzyloxy-phenyl)-4-(3-cyclopentyloxy-4-methoxy-phenyl)-pyrrolidin-2-one
• Synonyms: 1-(3-Benzyloxy-phenyl)-4-(3-cyclopentyloxy-4-methoxy-phenyl)-pyrrolidin-2-one
• CAS NO: 220284-70-8
• Molecular Weight: 457.569
• Mol File: 220284-70-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(3-Benzyloxy-phenyl)-4-(3-cyclopentyloxy-4-methoxy-phenyl)-pyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-Benzyloxy-phenyl)-4-(3-cyclopentyloxy-4-methoxy-phenyl)-pyrrolidin-2-one(220284-70-8)
• EPA Substance Registry System: 1-(3-Benzyloxy-phenyl)-4-(3-cyclopentyloxy-4-methoxy-phenyl)-pyrrolidin-2-one(220284-70-8)

Safety Data

• Hazardous Substances Data: 220284-70-8(Hazardous Substances Data)

Upstream product

• 61413-54-5 Rolipram 
• 107623-21-2 1-(benzyloxy)-3-iodobenzene 

Downstream Products

• 220284-92-4 4-(3-Cyclopentyloxy-4-methoxy-phenyl)-1-(3-hydroxy-phenyl)-pyrrolidin-2-one 

Relevant articles and documents

N-arylrolipram derivatives as potent and selective PDE4 inhibitors

Derivatization of rolipram led to the identification of 3-[4-(3- cyclopentyloxy-4-methoxypbenyl)-2-oxo-pyrrolidin-1-yl]-5-(3- methoxybenzyloxy)-benzoic acid N',N'-dimethylhydrazide (4), a potent and selective inhibitor of PDE4, which inhibits the activation of human leukocytes with pIC50 values in the range of 7.3 - 7.8, and blocks antigen induced eosinophilia in Brown Norway rats at a dose of 1 mg/kg (i.t.).

Synthesis of N-arylrolipram derivatives - Potent and selective phosphodiesterase-IV inhibitors - by copper catalyzed lactam-aryl halide coupling

The copper catalysed coupling of rolipram (1) with a wide variety of aryl halides (2) affords N-arylrolipram derivatives (3), potent and selective phosphodiesterase type-IV inhibitors.