220284-88-8Relevant academic research and scientific papers
Synthesis of N-arylrolipram derivatives - Potent and selective phosphodiesterase-IV inhibitors - by copper catalyzed lactam-aryl halide coupling
Aebischcr, Esther,Bacher, Edmond,Joachim Demnitz,Keller, Thomas H.,Kurzmeyer, Miriam,Ortiz, Marta L.,Pombo-Villar, Esteban,Weber, Hans-Peter
, p. 2225 - 2229 (2007/10/03)
The copper catalysed coupling of rolipram (1) with a wide variety of aryl halides (2) affords N-arylrolipram derivatives (3), potent and selective phosphodiesterase type-IV inhibitors.
