220293-63-0Relevant academic research and scientific papers
Syntheses of S,N-substituted 2-mercaptobenzenesulfonamide derivatives with potential pharmacological activity
Pomarnacka, Elzbieta,Kornicka, Anita
, p. 297 - 304 (2007/10/03)
A series of [5-chloro-4-methyl-2-sulfamoylphenyl(thio or sulfonyl)]alkanoic acids [I-VI], their methyl esters [VII-XII] and hydrazides [XIII-XXI] were prepared. The treatment of the selected esters [VII-VIII, XI-XII] with appropriate biguanide hydrochlorides gave 4-chloro-5-methyl-2-[2-amino-6-R3-triazin-4-ylalkyl(thio or sulfonyl)]benzenesulfonamides [XXII-XXVII]. The anticancer activity was observed in vitro for compound [XXII].
