220306-75-2

Upstream product

• 220306-69-4 (E)-(S)-5-Methyl-4-(2,4,6-trimethyl-benzenesulfonylamino)-hex-2-enoic acid methyl ester 
• 139192-50-0 (2S)-N-(2,4,6-trimethylbenzenesulfonyl)-2-amino-3-methyl-butanol 
• 148838-43-1 N-((S)-1-Formyl-2-methyl-propyl)-2,4,6-trimethyl-benzenesulfonamide 

Downstream Products

• 220306-83-2 Methanesulfonic acid (E)-(S)-5-methyl-4-(2,4,6-trimethyl-benzenesulfonylamino)-hex-2-enyl ester 
• 220306-79-6 Carbonic acid methyl ester (E)-(S)-5-methyl-4-(2,4,6-trimethyl-benzenesulfonylamino)-hex-2-enyl ester 
• 187532-11-2 (2R,3S)-3-Isopropyl-N-(2,4,6-trimethylphenylsulfonyl)-2-vinylaziridine 
• 187532-12-3 (2S,3S)-3-Isopropyl-N-(2,4,6-trimethylphenylsulfonyl)-2-vinylaziridine 

Relevant academic research and scientific papers

A 2,3-cis-selective synthesis of aziridines bearing a vinyl group from allyl methyl carbonates and allyl mesylates

A convenient method for the synthesis of synthetically useful chiral 2-vinylaziridines from natural α-amino acids is described. Satisfactory 2,3-cis-selectivities are obtained by exposure of methyl carbonates of various allylic alcohols bearing an N-protected amino group to a catalytic amount of tetrakis(triphenylphosphine)palladium(0), Pd(PPh3)4, in aprotic solvents such as THF. Base-promoted aziridination of mesylates of various N-protected amino allylic alcohols followed by Pd(PPh3)4 catalyzed isomerization for the 2,3-cis-selective synthesis of vinylaziridines is also presented.