220315-40-2Relevant academic research and scientific papers
Asymmetric synthesis of β-amino acid derivatives incorporating a broad range of substitution patterns by enolate additions to tert-butanesulfinyl imines
Tang, Tony P.,Ellman, Jonathan A.
, p. 7819 - 7832 (2007/10/03)
Addition of Ti(Oi-Pr)3 ester enolates to tert-butanesulfinyl aldimines and ketimines provided β-substituted, α,β and β,β-disubstituted, α,β,β- and α,α,β-trisubstituted, and α,α,β,β-tetrasubstituted β-amino acid derivatives in high yields and with high diastereoselectivites. The N-sulfinyl-β-amino ester products were further employed as versatile intermediates for both standard solution-phase and solid-phase synthetic transformations, including the synthesis of β-peptide foldamers.
