220316-48-3Relevant academic research and scientific papers
C-Glycosides to fused polycyclic ethers
Allwein, Shawn P.,Cox, Jason M.,Howard, Brett E.,Johnson, Henry W.B.,Rainier, Jon D.
, p. 1997 - 2009 (2007/10/03)
This manuscript describes the synthesis of fused polycyclic ethers from the coupling of C-glycoside forming reactions with ring closing metathesis and acid mediated annulation reactions.
A highly efficient iterative approach to fused ether ring systems
Rainier, Jon D.,Allwein, Shawn P.
, p. 9601 - 9604 (2007/10/03)
An iterative synthesis of fused ether ring systems has been developed. This strategy couples a cyclic enol ether oxidation and carbon-carbon bond forming reaction in one flask with an acid catalyzed cyclic acetal formation and alkoxide elimination in another flask. The result is a general and highly efficient two flask synthesis of fused ethers as are present in a wide variety of bioactive natural products.
