220316-75-6Relevant articles and documents
Copper-Catalyzed Enantioselective Sonogashira Type Coupling of Alkynes with α-Bromoamides
Chen, Bin,Mo, Xueling,Zhang, Guozhu
supporting information, p. 13998 - 14002 (2020/06/10)
An asymmetric copper-catalyzed Sonogashira type coupling between alkynes and α-bromoamides has been developed. This method represents a facile approach to synthetically useful β, γ-alkynyl amides from two readily available starting materials in a highly enantioselective manner. A Bisoxazoline diphenylanaline (BOPA) serves as the effective chiral ligand. Preliminary mechanistic studies support the formation of alkyl radical species.