220317-18-0Relevant academic research and scientific papers
3',4'-dihydrospiro[piperidine-4,2'-(1'H)quinoline] derivatives as new antioxidant agents with acetylcholinesterase inhibitory property
Kouznetsov, Vladimir V.,Me?ndez, Leonor Y. Vargas,Acevedo, Amner Mun?oz
, p. 710 - 715 (2013/01/09)
In vitro radical-cation scavenging capacity and anti-AChE activities of 19 piperidine derivatives, including dihy-drospiro[piperidine-4,2'(1'H)quinolines] 7-19 and their precursor 4-allyl-4-arylaminopiperidines 1-6 were reported. Their data of bioassays a
An efficient synthesis of new 1-H-4′-methyl-3′,4′-dihydrospiro[piperidine-4,2′(1′H)quinoline] scaffolds
Vargas Méndez, Leonor Y.,Kouznetsov, Vladimir V.
, p. 2509 - 2512 (2008/02/02)
Efficient synthesis of new 3′,4′-dihydrospiro[piperidine-4,2′(1′H)quinolines] by a four step synthetic route based on 1-benzyl-4-piperidone reactivity is reported.
A new series of M3 muscarinic antagonists based on the 4-amino-piperidine scaffold
Diouf,Gadeau,Chelle,Gelbcke,Talaga,Christophe,Gillard,Massingham,Guyaux
, p. 2535 - 2539 (2007/10/03)
A series of 4-amino-piperidine containing molecules have been synthesized and structure-affinity relationship toward the M3-muscarinic receptor has been investigated. Chemical modulations provided molecules with Ki for the human M3-R up to 1 nM with variable selectivity (3- to 40-fold) over the human M2-R. Compounds 2 (pA2=8.3, 8.6) demonstrates in vitro on guinea pig bladder and ileal strips potent anticholinergic properties and tissue selectivity.
