220364-79-4

Basic information

• Product Name: 1H-1,4-DIAZEPINE-5-CARBOXYLIC ACID, HEXAHYDRO-1,4-BIS(PHENYLMETHYL)-, METHYL ESTER
• Synonyms: 1H-1,4-DIAZEPINE-5-CARBOXYLIC ACID, HEXAHYDRO-1,4-BIS(PHENYLMETHYL)-, METHYL ESTER;1H-1,4-DIAZEPINE-5-CARBOXYLIC ACID, HEXAHYDRO-1,4-BIS(PHENYLMETHYL)-METHYL ESTER,DIHYDROCHLORIDE;Hexahydro-1,4-Bis(Phenylmethyl)-1H-1,4-Diazepine-5-Carboxylic Acid,Methyl Ester;1H-1,4-Diazepine-5-carboxylic acid;hexahydro-1,4-bis(phenylmethyl)-,methyl ester
• CAS NO: 220364-79-4
• Molecular Formula: C₂₁H₂₆N₂O₂
• Molecular Weight: 338.44
• Mol File: 220364-79-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 438.5±45.0 °C(Predicted)
• Appearance: /
• Density: 1.126±0.06 g/cm3(Predicted)
• PKA: 7.59±0.40(Predicted)
• CAS DataBase Reference: 1H-1,4-DIAZEPINE-5-CARBOXYLIC ACID, HEXAHYDRO-1,4-BIS(PHENYLMETHYL)-, METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-1,4-DIAZEPINE-5-CARBOXYLIC ACID, HEXAHYDRO-1,4-BIS(PHENYLMETHYL)-, METHYL ESTER(220364-79-4)
• EPA Substance Registry System: 1H-1,4-DIAZEPINE-5-CARBOXYLIC ACID, HEXAHYDRO-1,4-BIS(PHENYLMETHYL)-, METHYL ESTER(220364-79-4)

Safety Data

• Hazardous Substances Data: 220364-79-4(Hazardous Substances Data)

Usage

Type of compound

Methyl ester derivative of hexahydro-1,4-bis(phenylmethyl)-1H-1,4-diazepine-5-carboxylic acid

Common use

Medicinal and pharmaceutical research

Potential pharmacological and biological activities

Anti-anxiety and anti-depressant agent

Potential therapeutic applications

Treating neurological disorders and central nervous system disorders

Additional research needed

Further studies required to fully understand its properties and potential applications.

InChI:InChI=1/C21H26N2O2.2ClH/c1-25-21(24)20-12-13-22(16-18-8-4-2-5-9-18)14-15-23(20)17-19-10-6-3-7-11-19;;/h2-11,20H,12-17H2,1H3;2*1H

Upstream product

• 29547-04-4 methyl 2,4-dibromobutanoate 
• 140-28-3 N,N'-Dibenzylethylenediamine 

Downstream Products

• 405160-72-7 (1,4-dibenzyl-1,4-diazepan-5-yl)methanol 
• 220364-84-1 1,4-dibenzyl-1,4-diazepane-5-carboxamide 

Relevant articles and documents

METALLO-BETA-LACTAMASE INHIBITORS AND METHODS OF USE THEREOF

The present invention relates to metallo-β-lactamase inhibitor compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein Z, RA, X1, X2 and R1 are as defined herein. The present invention also relates to compositions which comprise a metallo-β-lactamase inhibitor compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, optionally in combination with a beta lactam antibiotic and/or a beta-lactamase inhibitor. The invention further relates to methods for treating a bacterial infection comprising administering to a patient a therapeutically effective amount of a compound of the invention, in combination with a therapeutically effective amount of one or more β-lactam antibiotics and optionally in combination with one or more beta-lactamase inhibitor compounds. The compounds of the invention are useful in the methods described herein for overcoming antibiotic resistance.

Preparation of ring-bridged bis-quinolines for the treatment of degenerative diseases of the central nervous system.

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