220378-76-7

Upstream product

• 184030-88-4 4-[1-(Triphenylmethyl)imidazol-4-yl]butan-1-al 
• 406225-22-7 4-(3-(1,3-dioxolan-2-yl)propyl)-1-trityl-1H-imidazole 
• 406225-21-6 (Z)-4-(3-(1,3-dioxolan-2-yl)prop-1-enyl)-1-trityl-1H-imidazole 
• 33016-47-6 (1-tritylimidazol-4-yl)carboxaldehyde 

Relevant academic research and scientific papers

ω-(Imidazol-4-yl)alkane-1-sulfonamides: a new series of potent histamine H3 receptor antagonists

ω-(1H-Imidazol-4-yl)alkane-1-sulfonamides were prepared and found to be potent histamine H3 receptor antagonists. High receptor affinity and a low difference in the data between the bioassays were achieved with 5-(1H-imidazol-4-yl)pentane-1-sulfonic acid 4-chlorobenzylamide (16). Good in vitro profiles were also obtained for 2-hydroxysulfonamide and vinylsulfonamide analogues. This complements and completes the existing set of imidazole-based sulfonamides and sulfamides. Copyright

1H-4(5)-substituted imidazole derivatives, their preparation and their use as histamine H3 receptor ligands

A compound of the formula wherein R2is an optionally substituted Czto Cgalkylene or alkylene chain; R3is C2to C15optionally substituted hydrocarbyl; X is a bond or —NR4—, wherein