2204-99-1Relevant academic research and scientific papers
Indium-copper and indium-silver mediated Barbier-Grignard-type alkylation reaction of aldehydes using unactivated alkyl halides in water
Shen, Zhi-Liang,Yeo, Yan-Lin,Loh, Teck-Peng
, p. 3922 - 3924 (2008/09/19)
(Chemical Equation Presented) An efficient method has been developed for the Barbier-Grignard-type alkylation reaction of aldehydes (including aliphatic version) using unactivated alkyl halides in water in the presence of an In/CuI/I2 or In/AgI/I2 system. The reactions proceeded more efficiently in water than in organic solvent. In, CuI or AgI, and I 2 were all essential for the efficient progress of the reactions. A radical-type reaction mechanism was studied and proposed by using 4-pentenal as substrate.
A new method for alkylation of aromatic aldehydes using alkylboron chloride derivatives in the presence of oxygen
Kabalka, George W,Wu, Zhongzhi,Ju, Yuhong
, p. 3243 - 3248 (2007/10/03)
Reactions of aromatic aldehydes with alkylboron chloride derivatives in the presence of oxygen have been investigated. Dialkylboron chlorides react with aryl aldehydes to produce arylalkylmethanols in good to excellent yields. Under the same reaction conditions, alkylboron dichlorides lead to the formation of arylalkyl chlorides.
