22043-24-9

Usage

Classification

Thiosemicarbazide derivative
A type of chemical compound containing a cyanobenzylidene group and a hydrazine group attached to a carbothioamide.

Potential Applications

Anti-tuberculosis agent, anti-cancer agent
The compound has been studied for its potential to treat tuberculosis and cancer due to its unique structure and properties.

Structure and Properties

Promising candidate for further research and development
The compound's structure and properties make it a valuable subject for investigation in the field of medicinal chemistry.

InChI:InChI=1/C9H8N4S/c10-5-7-1-3-8(4-2-7)6-12-13-9(11)14/h1-4,6H,(H3,11,13,14)

Upstream product

• 79-19-6 thiosemicarbazide 
• 105-07-7 4-cyanobenzaldehyde 

Downstream Products

• 40104-29-8 4-(5-amino-[1,3,4]thiadiazol-2-yl)benzonitrile 
• 1424369-97-0 4-(4-tert-butyl-4H-1,2,4-triazol-3-yl)benzonitrile 
• 1424370-14-8 C₁₃H₁₆N₄ 
• 1424370-40-0 C₁₈H₁₈N₄O 
• 1424370-10-4 4-(4-(4-methoxyphenethyl)-4H-1,2,4-triazol-3-yl)benzonitrile 

Relevant academic research and scientific papers

Synthesis, antimicrobial and antioxidant evaluation with in silico studies of new thiazole Schiff base derivatives

A series of nineteen thiazole Schiff base derivatives 2a-2s were synthesized (Scheme 1) and elucidated by spectral analyses (IR, 1H NMR and HRMS). The evaluation of their antimicrobial activities against two gram-positive, two gram-negative, an

Synthesis, Antileishmanial Activity and In Silico Studies of Aminoguanidine Hydrazones (AGH) and Thiosemicarbazones (TSC) Against Leishmania chagasi Amastigotes

Background: Leishmaniasis is a worldwide health problem, highly endemic in developing countries. Among the four main clinical forms of the disease, visceral leishmaniasis is the most se-vere, fatal in 95% of cases. The undesired side-effects from first-li

Synthesis of 2-amino-1,3,4-oxadiazoles and 2-Amino-1,3,4-thiadiazoles via sequential condensation and I2-mediated oxidative C-O/C-S bond formation

2-Amino-substituted 1,3,4-oxadiazoles and 1,3,4-thiadiazoles were synthesized via condensation of semicarbazide/thiosemicarbazide and the corresponding aldehydes followed by I2-mediated oxidative C-O/C-S bond formation. This transition-metal-free sequential synthesis process is compatible with aromatic, aliphatic, and cinnamic aldehydes, providing facile access to a variety of diazole derivatives bearing a 2-amino substituent in an efficient and scalable fashion.