220446-69-5

Upstream product

• 3042-22-6 2-phenyl-1H-pyrrole 
• 271585-91-2 ethyl 1-(N-tert-butoxycarbonyl)-5-phenyl-2-pyrrolylacetate 
• 1031223-78-5 C₁₈H₁₀F₅NO₂ 
• 64-17-5 ethanol 
• 201230-82-2 carbon monoxide 
• 145822-68-0 (E)-[2-ethoxy-3-(ethoxycarbonyl)-2-propenylidene]triphenylphosphorane 
• 271585-83-2 (+/-)-ethyl 6-(N-tert-butoxycarbonyl)amino-3-ethoxy-6-phenylhexa-2,4-dienoate 
• 140196-38-9 1,1-dimethyl (2-oxo-1-phenylethyl)carbamate 

Downstream Products

• 5449-90-1 (5-phenyl-pyrrol-2-yl)-acetic acid 

Relevant academic research and scientific papers

Synthesis of 5-phenyl 2-functionalized pyrroles by amino Heck and Tandem amino Heck carbonylation reactions

2-Methyl-, 2-(methoxycarbonyl)methyl-, and 2,2-[(ethoxycarbonyl) (methoxycarbonyl)]methyl-5-phenylpyrroles are prepared from the corresponding 3-butynyl and 4-(methoxycarbonyl)-3-butynyl phenyl ketone O-pentafluorobenzoyl oximes by amino Heck cyclization

Synthesis of Dihydropyrrole and Pyrrole Derivatives by Radical Cyclization of γ,δUnsaturated Ketone O-Acetyloximes

Treatment of γδ-unsaturated ketone O-acetyloximes with a catalytic amount of 1,5-naphthalenediol or hydroquinone, acetic acid, and 1,4-cyclohexadiene affords various dihydropyrrole and pyrrole derivatives via radical cyclization induced by one-electron reduction of the oximes.

Synthesis of pyrrole derivatives by palladium-catalyzed cyclization of γ,δ-unsaturated ketone o-pentafluorobenzoyloximes

Various pyrrole derivatives are synthesized from γ,δ-unsaturated ketone O-pentafluorobenzoyloximes by treatment with catalytic amounts of Pd(PPh3)4 and triethylamine via alkylideneaminopalladium(II) intermediates generated by oxidative addition of the oximes to the Pd(0) complex.

A facile synthesis of 5-substituted 2-furyl-, 2-thienyl- and 2- pyrrolylacetates by cyclodehydration of γ-functionalized α,β-unsaturated ketones

Synthesis of 5-substituted 2-furyl-, 2-thienyl- and 2-pyrrolylacetates is achieved by acid-catalyzed cyclodehydration of γ-hydroxy (γ-acetylthio and γ-amino)-α,β-unsaturated ketones generated from ethyl 6-substituted 3- ethoxy-6-hydroxy-(6-acetylthio and 6-amino)hexa-2,4-dienoates which are easily accessible from α-functionalized carbonyl compounds and Wittig reagents.

Synthesis of pyrrole derivatives by the heck-type cyclization of γ,δ-unsaturated ketone O-pentafluorobenzoyloximes

Substituted pyrroles are synthesized from γδ-unsaturated ketone O-pentafluorobenzoyloximes by the intramolecular Heck-type amination of the olefinic moiety catalyzed by Pd(PPh3)4.