220495-98-7

Usage

Chemical compound

3-methoxy-2-nitro-N-phenylaniline

Properties

nitroaniline derivative, containing nitro group, methoxy group, and phenyl group

Uses

intermediate in synthesis of dyes, pigments, pharmaceuticals, agrochemicals; potential uses in organic synthesis and chemical research

Color

yellow to orange

Synthesis

through nitration and N-arylation reactions

Health hazards

precautions should be taken when handling and using this chemical

Upstream product

• 108-86-1 bromobenzene 
• 16554-47-5 3-methoxy-2-nitroaniline 
• 500298-30-6 2-bromo-6-methoxynitrobenzene 
• 62-53-3 aniline 

Downstream Products

• 667918-95-8 4-methoxy-1-phenylbenzimidazole 

Relevant academic research and scientific papers

Novel benzimidazole derivatives as phosphodiesterase 10A (PDE10A) inhibitors with improved metabolic stability

In this study, we report the identification of potent benzimidazoles as PDE10A inhibitors. We first identified imidazopyridine 1 as a high-throughput screening hit compound from an in-house library. Next, optimization of the imidazopyridine moiety to improve inhibitory activity gave imidazopyridinone 10b. Following further structure-activity relationship development by reducing lipophilicity and introducing substituents, we acquired 35, which exhibited both improved metabolic stability and reduced CYP3A4 time-dependent inhibition.

Structure-activity relationships for 1-phenylbenzimidazoles as selective ATP site inhibitors of the platelet-derived growth factor receptor

1-Phenylbenzimidazoles are shown to be a new class of ATP-site inhibitors of the platelet-derived growth factor receptor (PDGFR). Structure- activity relationships (SARs) are narrow, with closely related heterocycles being inactive. A systematic study of