220499-12-7

Upstream product

• 59382-59-1 2-methyl-3-nitro-benzoic acid methyl ester 
• 1975-50-4 2-methyl-3-nitrobenzic acid 
• 1313237-54-5 1-(tert-butyl) 4-methyl indoline-1,4-dicarboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 73816-11-2 Methyl trans-2-<β-(dimethylamino)vinyl>-3-nitrobenzoate 
• 39830-66-5 methyl 1H-indole-4-carboxylate 
• 220499-11-6 1-(tert-butyl) methyl 1H-1,4-indoledicarboxylate 

Downstream Products

• 220499-13-8 tert-butyl 4-(bromomethyl)-1H-1-indolecarboxylate 
• 1352721-25-5 N-(2-{4-[2-acetylimino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-piperidin-1-yl}-4-methyl-phenyl)-acetamide 
• 1352721-65-3 4-{3-[1-(2-acetylamino-5-methyl-phenyl)-piperidin-4-yl]-2-imino-2,3-dihydro-benzoimidazol-1-ylmethyl}-indole-1-carboxylic acid tert-butyl ester 
• 1352720-96-7 N-(2-{4-[2-imino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-piperidin-1-yl}-4-methyl-phenyl)-acetamide 
• 1352721-16-4 N-(4-chloro-2-{4-[2-imino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-piperidin-1-yl}-phenyl)-acetamide 
• 1352721-51-7 4-{3-[1-(2-amino-5-chloro-phenyl)-piperidin-4-yl]-2-[tert-butoxycarbonylimino]-2,3-dihydro-benzoimidazol-1-ylmethyl}-indole-1-carboxylic acid tert-butyl ester 
• 1352721-52-8 4-{2-[tert-butoxycarbonylimino]-3-[1-(5-chloro-2-nitro-phenyl)-piperidin-4-yl]-2,3-dihydro-benzoimidazol-1-ylmethyl}-indole-1-carboxylic acid tert-butyl ester 
• 1352721-53-9 1-[1-(5-chloro-2-nitro-phenyl)-piperidin-4-yl]-3-(1H-indol-4-ylmethyl)-1,3-dihydro-benzoimidazol-2-ylideneamine 
• 1352873-16-5 N-{5-chloro-4'-[2-imino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-acetamide 
• 1352874-54-4 4-[2-[(E)-tert-butoxycarbonylimino]-3-(2'-carboxy-5'-chloro-biphenyl-4-yl)-2,3-dihydro-benzoimidazol-1-ylmethyl]-indole-1-carboxylic acid tert-butyl ester 
• 1352873-26-7 6-acetylamino-4'-[2-imino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-3-carboxylic acid dimethylamide 
• 1352873-28-9 N-(6-chloro-2-{4-[2-imino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-phenyl}-pyridin-3-yl)-acetamide 
• 1352873-29-0 N-(5-chloro-3-{4-[2-imino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-phenyl}-pyridin-2-yl)-acetamide 
• 1352873-77-8 N-(4-chloro-2-{5-[2-imino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-pyridin-2-yl}-phenyl)-acetamide 

Relevant academic research and scientific papers

Discovery of potent, selective chymase inhibitors via fragment linking strategies

Chymase plays an important and diverse role in the homeostasis of a number of cardiovascular processes. Herein, we describe the identification of potent, selective chymase inhibitors, developed using fragment-based, structure-guided linking and optimizati

BIPHENYL SUBSTITUTED 1,3-DIHYDRO-BENZOIMIDAZOL-2-YLIDENEAMINE DERIVATIVES

The invention relates to new derivatives of formula (I), wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of one or more IGF-1R mediated disorders or diseases

PIPERIDINYL SUBSTITUTED 1,3-DIHYDRO-BENZOIMIDAZOL-2-YLIDENEAMINE DERIVATIVES

The invention relates to new derivatives of formula (I) wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of one or more IGF-1R mediated disorders or diseases

INDOLE AND INDAZOLE ANALOGS AS GLYCOGEN SYNTHASE ACTIVATORS

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful

Neo-tryptophan

The invention provides a novel amino acid, neo-tryptophan, as well as polypeptides containing this novel amino acid such as neurotensin analogs. In addition, the invention provides neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and polypeptides containing such derivatives. The invention also provides methods for making neo-tryptophan, neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and compositions containing these compounds. Further, the invention provides methods for inducing a neurotensin response in a mammal as well as methods for treating a mammal having a serotonin recognition molecule.

Synthesis of (2S)-2-amino-3-(1H-4-indolyl)propanoic acid, a novel tryptophan analog for structural modification of bioactive peptides

A convenient, multigram synthesis of a novel α-amino acid (2S)-2- amino-3-(1H-4-indolyl)propanoic acid (la), is reported. An Fmoc-t-Boc derivative of this novel regioisomer of the natural aromatic amino acid tryptophan could be readily incorporated into b