220504-75-6

Usage

Uses

Used in Pharmaceutical Industry:
Benzoic acid, 2,4-dimethyl-5-nitro(9CI) is used as a precursor in the synthesis of various pharmaceuticals for its potential antimicrobial and antifungal properties. It aids in the development of new drugs that can combat resistant strains of bacteria and fungi.
Used in Agrochemical Industry:
In the agrochemical industry, Benzoic acid, 2,4-dimethyl-5-nitro(9CI) is utilized as a starting material for the synthesis of agrochemicals with antimicrobial and antifungal properties. This helps in developing agricultural products that protect crops from diseases and pests, thereby increasing crop yield and quality.
Used in Dye Manufacturing:
Benzoic acid, 2,4-dimethyl-5-nitro(9CI) is used in the manufacturing of dyes due to its chemical properties. It contributes to the production of a wide range of dyes with diverse color characteristics, used in various applications such as textiles, plastics, and printing inks.
Used in Perfumery:
This chemical compound is also used in the perfumery industry as a component in the creation of various fragrances. Its unique chemical structure allows it to contribute to the development of distinct and complex scents in perfumes and other fragranced products.
Used in Flavoring Agents Production:
Benzoic acid, 2,4-dimethyl-5-nitro(9CI) is employed in the production of flavoring agents, where its chemical properties contribute to the development of unique and desirable flavors in food and beverage products. Its use in this industry helps create a diverse range of taste profiles for consumers to enjoy.

InChI:InChI=1/C9H9NO4/c1-5-3-6(2)8(10(13)14)4-7(5)9(11)12/h3-4H,1-2H3,(H,11,12)

Upstream product

• 610-91-3 5-nitropseudocumene 
• 13621-23-3 1-(2,4-dimethyl-5-nitro-phenyl)-ethanone 
• 611-01-8 2,4-dimethyl-benzoic acid 
• 7697-37-2 nitric acid 
• 861776-98-9 1-(2,4-dimethyl-5-nitro-phenyl)-butan-1-one 
• 89-74-7 2,4-dimethylacetophenone. 

Downstream Products

• 791722-05-9 Ethyl-5-amino-2.4-dimethylbenzoat 
• 202264-66-2 methyl 2,4-dimethyl-5-nitrobenzoate 
• 1191428-68-8 C₉H₁₁NO₃ 
• 220504-79-0 5-(2,2-(bis(ethoxycarbonyl)-2-phenylacetamido)ethyl)-6-acetoxy-3H-isobenzofuran-1-one 
• 220504-82-5 3,4-dihydro-3-(phenylacetamido)-2,5-dihydro-2-oxofuro<3,4-d>-2H-1-benzopyran-2-one 
• 220504-77-8 methyl 2,4-bis-(bromomethyl)-5-acetoxybenzoate 
• 220504-76-7 methyl 2,4-dimethyl-5-acetoxybenzoate 
• 140112-97-6 methyl 5-amino-2,4-dimethylbenzoate 
• 50790-71-1 methyl 2,4-dimethyl-5-hydroxybenzene-1-carboxylate 
• 50790-68-6 2,4-dimethyl-5-hydroxybenzoic acid 
• 854854-47-0 5-nitro-2,4-dimethylbenzoyl chloride 
• 873986-84-6 2,4-dimethyl-5-nitro-benzophenone 

Relevant academic research and scientific papers

Synthesis method of 2, 4-dimethyl-3-methylsulfonylbenzoic acid

The invention discloses a synthesis method of 2, 4-dimethyl-3-methylsulfonylbenzoic acid. The method comprises the following steps of: nitrifying 2, 4-dimethylbenzoic acid serving as a raw material byusing concentrated nitric acid, carrying out NIS iodination, iron powder acetic acid reduction, hypophosphorous acid and sodium nitrite system deamination, carrying out methylthiolation by using dimethyl disulfide, oxidizing by using peracetic acid, extracting the reaction solution by using dichloromethane after the reaction is finished, drying, and carrying out spin-drying to obtain the target product 2, 4-dimethyl-3-methylsulfonylbenzoic acid. The method has the advantages of easily available raw materials, feasible route, simple operation, high product purity and low cost.

Discovery of N-(3-(morpholinomethyl)-phenyl)-amides as potent and selective CB2 agonists

Recently sulfamoyl benzamides were identified as a novel series of cannabinoid receptor ligands. Replacing the sulfonamide functionality and reversing the original carboxamide bond led to the discovery of N-(3-(morpholinomethyl)-phenyl)-amides as potent and selective CB2 agonists. Selective CB2 agonist 31 (Ki = 2.7; CB1/CB2 = 190) displayed robust activity in a rodent model of postoperative pain.

Synthesis and reactivity with β-lactamases of 'penicillin-like' cyclic depsipeptides

Several 7-carboxy-3-amido-3,4-dihydro-2H-1-benzopyran-2-ones have been synthesized as potential β-lactamase substrates and/or mechanism-based inhibitors. Substituted o-tyrosine precursors were prepared by the Sorensen method and then heated in vacuo to give the lactones. These compounds are cyclic analogues of aryl phenaceturates which are known to be β-lactamase substrates. The goal of incorporating the scissile ester group into a lactone was to retain the leaving group tethered to the acyl moiety at the acyl- enzyme stage of turnover by serine β-lactamases, in a manner similar to that during penicillin turnover. Further, in two cases, a functionalized methylene group para to the leaving group phenoxide oxygen was incorporated. These molecules possess a latent p-quinone methide electrophile which could, in principle, be unmasked during enzymic turnover and react with an active site nucleophile. All of these compounds were found to be substrates of class A and C β-lactamases, the first δ-lactones with such activity. Generally, k(cat) values were smaller than for the analogous acyclic depsipeptides, which suggests that the tethered leaving group may obstruct the attack of water on the acyl-enzymes. Further exploration of this structural theme might lead to quite inert acyl-enzymes and thus to significant inhibitors. Despite the apparent advantage offered by the longer-lived acyl-enzymes, the functionalized compounds were no better as irreversible inhibitors than comparable acyclic compounds [Cabaret, D.; Liu, J.; Wakselman, M.; Pratt, R. F.; Xu, Y. Bioorg. Med. Chem. 1994, 2, 757-771]. Thus, even tethered quinone methides, at least when placed as dictated by the structures of the present compounds, were unable to efficiently trap a nucleophile at serine β- lactamase active sites.

Process for the production of nitro derivatives of aromatic compounds

Nitroderivates of aromatic compounds which are difficult to nitrate, can readily be obtained by nitration providing that the aromatic compound is treated with nitric acid or another nitrating agent in the presence of aliphatic or cycloaliphatic hydrocarbons monosubstituted or polysubstituted by halogen, the nitro group or an alkyl sulphonyl group, and the nitro derivative formed subsequently isolated.