22051-18-9Relevant academic research and scientific papers
Synthesis of 2-acyl- and 2-ethoxycarbonyl-3-alkylindoles from o-alkynyltrifluoroacetanilides
Arcadi, Antonio,Cacchi, Sandro,Fabrizi, Giancarlo,Marinelli, Fabio
, p. 647 - 649 (2007/10/03)
The reaction of readily available o-alkynyltrifluoroacetanilides with ethyl iodoacetate, ethyl bromoacetate or α-bromoke-tones in the presence of K2CO3 affords 2-ethoxycarbonyl- and 2-acyl-3-alkylindoles in good to high yield. The synthesis proceeds via an in situ sequential alkylation-cyclization process. Thieme Stuttgart.
