220511-65-9Relevant academic research and scientific papers
An improved route to 1,2-dideoxy-β-1-phenyl-D-ribofuranose
Wichai, Uthai,Woski, Stephen A.
, p. 3465 - 3468 (1998)
An efficient synthesis of the aryl nucleoside analogue 1,2-dideoxy-β- 1-phenyl-D-ribofuranose (1) is described. This route utilizes the addition of phenyllithium to a protected 2-deoxyribonolactone followed by reduction with triethylsilane/boron trifluoride etherate to selectively produce the β- anomer. Deprotection yields the desired aryl C-nucleoside in 27% overall yield from 2-deoxy-D-ribose.
Modular Synthesis of 4-aryl- and 4-amino-substituted benzene C-2′-Deoxyribonucleosides
Joubert, Nicolas,Urban, Milan,Pohl, Radek,Hocek, Michal
experimental part, p. 1918 - 1932 (2009/04/04)
A modular methodology for the syntheses of various 4-substituted-phenyl C-2′-deoxyribonucleosides has been developed. Coupling of toluoylated halogenose 1 with 4-bromophenylmagnesium bromide afforded the desired bis(toluoyl)-protected 1β-(4-bromophenyl)-1
