220515-17-3Relevant academic research and scientific papers
Design and synthesis of new secretory phospholipase A2 inhibitor of a phospholipid analog
Iwama, Seiji,Segawa, Masaki,Fujii, Shinobu,Ikeda, Kiyoshi,Katsumura, Shigeo
, p. 3495 - 3498 (2007/10/03)
All stereoisomers of N-acyl-4,5-disubstituted oxazolidinone phospholipid analogs were synthesized by regio and stereoselective epoxide ring opening accompanied by introduction of an amino group. The (4R,5S)-derivative showed stronger inhibitory activity toward type II phospholipase A2 than the 4- substituted oxazolidinone phospholipid analog previously reported.
