220548-73-2 Usage
Uses
Used in Pharmaceutical Industry:
(3S,4R)-4-(4-Fluorophenyl)piperidine-3-Methanol Hydrochloride is used as an intermediate for the synthesis of various pharmaceutical compounds, particularly those with antidepressant properties. Its specific stereochemistry allows for the development of targeted therapies with fewer side effects.
Used in Drug Synthesis:
As a key intermediate, (3S,4R)-4-(4-Fluorophenyl)piperidine-3-Methanol Hydrochloride is used in the production of N-Desmethyl Paroxetine, a metabolite of Paroxetine. (3S,4R)-4-(4-Fluorophenyl)piperidine-3-Methanol Hydrochloride plays a crucial role in the development of antidepressant medications, contributing to their overall efficacy and safety.
Used in Research and Development:
Due to its unique chemical properties, (3S,4R)-4-(4-Fluorophenyl)piperidine-3-Methanol Hydrochloride is also utilized in research and development for the discovery of new drugs and therapeutic agents. Its potential applications in various therapeutic areas are being explored, including its use in the treatment of neurological disorders and other conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 220548-73-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,0,5,4 and 8 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 220548-73:
(8*2)+(7*2)+(6*0)+(5*5)+(4*4)+(3*8)+(2*7)+(1*3)=112
112 % 10 = 2
So 220548-73-2 is a valid CAS Registry Number.
220548-73-2Relevant academic research and scientific papers
Enzymatic resolution of trans-4-(4′-fluorophenyl)-3-hydroxymethylpiperidines, key intermediates in the synthesis of (-)-Paroxetine
De Gonzalo,Brieva,Sanchez,Bayod,Gotor
, p. 8947 - 8953 (2007/10/03)
Two Candida antarctica lipases catalyze the enantioselective acylation of N-substituted trans-4-(4′-fluorophenyl)-3-hydroxymethylpiperidines in organic solvents. These two lipases show opposite stereochemical preference in these processes. Both enantiomers can be obtained in their optically pure forms. The (3S,4R) isomer, is an intermediate for the synthesis of (-)-Paroxetine.
