220554-11-0Relevant academic research and scientific papers
IMAGING AGENTS WITH IMPROVED PHARMACOKINETIC PROFILES
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Page/Page column 14-15, (2010/02/15)
The invention relates to compounds suitable for use in an imaging agent said imaging agent showing an improved pharmacokinetic profile.
Process for alkylating hindered sulfonamides
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, (2008/06/13)
The present invention relates to a process for alkylating hindered sulfonamides by Michael addition to propiolates, and to novel intermediates prepared in said process. The products of these reactions can be converted into pharmaceutical compounds useful
Aryloxyarylsulfonylamino hydroxamic acid derivatives
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, (2008/06/13)
A compound of the formula wherein X, Y, R1and R2are as defined above, useful in the treatment of arthritis or cancer and other diseases involving selective inhibition of matrix metaloproteinase-13.
Process for preparing hydroxamic acids
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, (2008/06/13)
The present invention relates to a process for preparing hydroxamic acids from hydroxylic acid intermediates wherein the carboxylic acid intermediate does not possess reactive substituents such as hydroxy or amino groups.
Process for alkylating hindered sulfonamides useful in the production of matrix metalloproteinase inhibitors
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, (2008/06/13)
The present invention relates to a process for alkylating hindered sulfonamides useful as intermediates in the preparation of matrix metalloproteinase inhibitors.
Process for preparing phenoxyphenylsulfonyl halides
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, (2008/06/13)
A process for preparing phenoxyphenylsulfonyl halides, which are useful intermediates for the preparation of matrix metalloproteinase inhibitors.
Process for alkylating hindered sulfonamides
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, (2008/06/13)
The present invention relates to a process for the preparation of compounds of formula (b), in which a compound of formula V is reacted with a compound of formula VI. The resulting compound of formula IV is reduced to a compound of formula III which is hy
