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4-iodo-5-phenyloxazole is an organic compound characterized by a five-membered oxazole ring, with an iodine atom at the 4-position and a phenyl group at the 5-position. This chemical is known for its potential applications in the synthesis of various pharmaceuticals and agrochemicals due to its unique structure and reactivity. The presence of the iodine atom makes it a valuable intermediate for further functionalization, while the phenyl group contributes to its stability and potential for molecular interactions. The compound is typically synthesized through a cyclization reaction involving a 2-iodoaniline and a phenylglyoxal derivative, and it is often used as a building block in the development of new molecules with specific biological activities.

220580-85-8

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220580-85-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 220580-85-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,0,5,8 and 0 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 220580-85:
(8*2)+(7*2)+(6*0)+(5*5)+(4*8)+(3*0)+(2*8)+(1*5)=108
108 % 10 = 8
So 220580-85-8 is a valid CAS Registry Number.

220580-85-8Relevant academic research and scientific papers

Oxazole Synthesis by Sequential Asmic-Ester Condensations and Sulfanyl-Lithium Exchange-Trapping

Mueller, Louis G.,Chao, Allen,Alwedi, Embarek,Natrajan, Maanasa,Fleming, Fraser F.

, p. 1500 - 1503 (2021/03/08)

Oxazoles are rapidly assembled through a sequential deprotonation-condensation of Asmic, anisylsulfanylmethylisocyanide, with esters followed by sulfanyl-lithium exchange-trapping. Deprotonating Asmic affords a metalated isocyanide that efficiently traps esters to afford oxazoles bearing a versatile C-4 anisylsulfanyl substituent. Interchange of the anisylsulfanyl substituent is readily achieved through a first-in-class sulfur-lithium exchange-electrophilic trapping sequence whose versatility is illustrated in the three-step synthesis of the bioactive natural product streptochlorin.

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