220628-89-7

Upstream product

• 25635-22-7 quinoline-8-carboxylic acid ethylester 
• 20989-17-7 (2S)-2-phenylglycinol 
• 2935-35-5 (S)-2-phenylglycine 
• 86-59-9 8-carboxyquinoline 
• 100517-41-7 quinoline-8-carbonyl chloride 

Downstream Products

• 426823-07-6 N-[(1S)-1-phenyl-2-hydroxyethyl]-(1,2,3,4-tetrahydroquinolin-8-yl)-carboxamide 
• 220628-99-9 8-[(4S)-4-phenyl-4,5-dihydro-1,3-oxazol-2-yl]quinoline 

Relevant academic research and scientific papers

Chiral 1,2,3,4-tetrahydroquinolinyl-oxazoline ligands for Ru-catalyzed asymmetric transfer hydrogenation of ketones

Chiral 1,2,3,4-tetrahydroquinolinyl-oxazoline compounds have been synthesized from 8-quinolinecarboxylic acid and enantiomerically pure amino alcohols using a convenient procedure. Asymmetric transfer hydrogenation of aryl ketones with the catalyst prepared in situ from [Ru(p-cymene)Cl2]2 and ligands 2 in 2-propanol in the presence of KOH, afforded the corresponding secondary alcohols in reasonable yields and up to 83% e.e.

Chiral quinolinyl-oxazolines as ligands for copper(I)-catalyzed asymmetric cyclopropanation

Chiral quinolinyl-oxazoline compounds have been synthesized from enantiomerically pure amino alcohols and 8-quinoline-carboxylic acid using a convenient procedure. Asymmetric cyccopropanation of styrene with diazoacetates in the presence of 1 mol% of CuOTf and quinolinyl-oxazolines gave 2-phenylcyclopropane carboxylates in moderate enantiomeric excesses.